While we have applied this approach to studying these changes in muscle and heart of DM patients, we are beginning to study the central nervous system, and trying to connect RNA changes to important symptoms such as sleepiness, fatigue, learning & memory, and executive functioning. This tool has allowed us to gain a comprehensive view of how RNA species are perturbed in DM and other diseases. A critical tool for us is deep sequencing, which allows us to obtain millions of data points in a single experiment, at low cost and time investment. We use a number of traditional molecular and cell biological approaches, as well as cutting edge sequencing and computational approaches. Our lab is focused on three main areas – 1) studying the pathogenesis of microsatellite repeat diseases, in particular myotonic dystrophy, 2) studying the basics of how RNA is processed and localized in cells in tissues, and 3) combining insights made in both of those areas to develop treatments for people with these diseases. He looks forward to helping to build a cohesive team capable of achieving more by working together rather than independently. In 2015, he decided to move his lab to the Center for Neurogenetics, in order to work more closely with like-minded individuals focused on understanding microsatellite repeat diseases. In 2013, Eric received an NIH Director’s Early Independence Award, which allowed him to launch his lab at MIT. In more recent work, he has shown that the MBNL and CELF proteins, both implicated in DM, antagonize each other’s functions in the nucleus (splicing) and cytoplasm (RNA localization and stability). He later applied these technologies to studying functions of the Muscleblind proteins, which play a key role in DM, uncovering an unanticipated global role for these proteins in regulating the localization of RNAs to specific subcellular compartments. Eric has published key work characterizing the use of deep sequencing technologies to study RNA species across the entire transcriptome, and found that over 95% of human multi-exonic genes are alternatively spliced, the majority in a tissue-regulated manner. There, he trained in computational biology, as well as learned about diseases such as DM, Huntington’s disease, and ALS. Eric received his PhD from Harvard-MIT Division of Health Sciences and Technology, mentors Christopher Burge and David Housman. He is personally motivated to better understand DM and related diseases, and to find treatments. of Molecular Genetics & MicrobiologyĮric has always been interested in understanding how biological systems function, but in part entered this field and joined the team at UF because he has family members affected by myotonic dystrophy. 4th Annual Strength, Science and Stories of Inspiration EventĪssistant Professor- Molecular Genetics &Microbiologyĭept.CNG Attends the IDMC-11 and MDF Conferences in San Francisco.2020 Fourth International Brainstorm Symposium – Updated.Promise to Kate Graduate Student Fellowships.New study shows antibody therapy could offer treatment path for genetic form of ALS and FTD.New preclinical study shows common diabetes drug improves symptoms in genetic form of ALS.
Lukasz Sznajder Awarded 2016 MDF Fellowship
Laura Ranum appointed to the Kitzman Family Professorship Marina Scotti awarded RO1 supplemental fellowship Jana Jenquin Awarded the NSF Graduate Research Fellowship.Promise to Kate Graduate Student Fellowship Awards.
Laura Ranum Named One of College of Medicine’s 2017-2018 University Term Professors.Laura Ranum Awarded the 2017 Steinert Award for DM Research.Awards Won at UF Drug Discovery Symposium.Eric Wang » Center for NeuroGenetics » College of Medicine » University of Florida
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